- L-694458; DMP-777; DMP777
货号： abs814253
| 货号-规格 | 货期 | 价格 | 数量 |
| abs814253-50mg | 1-2周 | ￥10419.00 | - + |
| abs814253-100mg | 1-2周 | ￥16317.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. | |
| 纯度 | >98% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）；
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
| 基本信息 | ||
| 别名 | L-694458; DMP-777; DMP777 | |
| 外观 | Powder | |
| 生物活性 | ||
| 靶点 | Elastase | |
| In vivo(体内研究) | DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministeredwith omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats thatreceive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
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Certificate of Analysis(COA)
