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  • DMP 777
    • L-694458; DMP-777; DMP777
    货号: abs814253
    CAS号: 157341-41-8
    分子式: C31H40N4O6
    分子量: 564.6725
    产品说明书
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    货号-规格 货期 价格 数量
    abs814253-50mg 1-2周 ¥10419.00
    - +
    abs814253-100mg 1-2周 ¥16317.00
    - +
    大包装询价
    产品描述
    描述

    DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    L-694458; DMP-777; DMP777
    外观
    Powder
    生物活性
    靶点
    Elastase
    In vivo(体内研究)
    DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministeredwith omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats thatreceive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.
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