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  • DMAT
    • Casein kinase II Inhibitor, CK2 Inhibitor
    货号: abs811645
    CAS号: 749234-11-5
    分子式: C9H7Br4N3
    分子量: 476.79
    产品说明书
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    货号-规格 货期 价格 数量
    abs811645-10mg 4周 ¥902.00
    - +
    abs811645-50mg 4周 ¥3226.00
    - +
    大包装询价
    产品描述
    描述

    DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Casein kinase II Inhibitor, CK2 Inhibitor
    可溶性/溶解性
    DMSO: ≥ 54 mg/mL
    生物活性
    靶点
    Casein Kinase
    In vitro(体外研究)
    DMAT (1 μM-2.5 μM) DMAT is more efficient in killing antiestrogen resistant cells than parental antiestrogen sensitive MCF-7 cells. DMAT-induced cell death of antiestrogen resistant cells is mediated by caspases. DMAT inhibits CK2 activity but the inhibition is similar in the three cell lines, MCF-7, TAMR-1 and 182R-6. DMAT has effects on H295R cell proliferation at concentrations of 10-4 and 10-5mol/Las compared with the control. DMAT (100 μM) significantly increases apoptosis of H295R cells. DMAT (1 nM-1 μM) significantly decreases aldosterone release into supernatants of 72-h H295R cell cultures as compared with the control. DMAT also inhibits PIM1 by a mechanism which is competitive with respect to ATP, and it is a powerful inhibitor of kinases other than CK2.
    In vivo(体内研究)
    DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue.
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    • 实验方法 实验条件
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