DJ-V-159
- DJ-V159
货号: abs821733
货号-规格 | 货期 | 价格 | 数量 |
abs821733-5mg | 现货 | ¥792.00 | - + |
abs821733-25mg | 现货 | ¥2112.00 | - + |

产品描述 | ||
描述 | DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A). | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | DJ-V159 | |
外观 | Off white powder | |
可溶性/溶解性 | DMSO : 25 mg/mL (49.76 mM; Need ultrasonic) | |
生物活性 | ||
靶点 | GPRC6A. | |
In vitro(体外研究) | DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A. | |
In vivo(体内研究) | DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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