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  • DJ-V-159

    • DJ-V159
    货号: abs821733
    CAS号: 2253744-53-3
    分子式: C24H12F6N4O2
    分子量: 502.37
    产品说明书
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    货号-规格 货期 价格 数量
    abs821733-5mg 现货 ¥792.00
    - +
    abs821733-25mg 现货 ¥2112.00
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    大包装询价
    产品描述
    描述
    DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    DJ-V159
    外观
    Off white powder
    可溶性/溶解性
    DMSO : 25 mg/mL (49.76 mM; Need ultrasonic)
    生物活性
    靶点
    GPRC6A.
    In vitro(体外研究)
    DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A.
    In vivo(体内研究)
    DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five.
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