Diquafosol tetrasodium
- 地夸磷索四钠;INS365
货号: abs821590
货号-规格 | 货期 | 价格 | 数量 |
abs821590-5mg | 现货 | ¥1058.00 | - + |
abs821590-50mg | 现货 | ¥4763.00 | - + |

产品描述 | ||
描述 | Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease. | |
纯度 | ≥98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 地夸磷索四钠;INS365 | |
外观 | White to off-white crystalline powder | |
可溶性/溶解性 | H2O : 100 mg/mL (113.87 mM; Need ultrasonic) DMSO : 1 mg/mL (1.14 mM; Need ultrasonic) | |
生物活性 | ||
In vitro(体外研究) | Cell viability significantly decreased after treatment with 30% diluted diquafosol for 1 hour and 6 hours after treatment with 10% and 20% diluted diquafosol. Twenty-four hours after wounding monolayers, 3% diquafosol, and 0.3% HCECs exhibits significantly more wound healing than the control. | |
In vivo(体内研究) | In a rat dry eye model, the P2Y2 agonist diquafosol tetrasodium is found to improve surface health, based on increases in tear fluid secretion, corneal epithelial resistance, and release of glycoprotein-containing moieties from goblet cells. Beginning at 2 weeks and continuing for an additional 2 weeks, maximal declines in dye penetrance of approximately 50% occurred with doses of diquafosol tetrasodium as low as 1%. INS365 significantly suppresses corneal damage at concentrations of more than 0.1% w/v. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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