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  • Diquafosol tetrasodium

    • 地夸磷索四钠;INS365
    货号: abs821590
    CAS号: 211427-08-6
    分子式: C18H22N4Na4O23P4
    分子量: 878.23
    产品说明书
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    货号-规格 货期 价格 数量
    abs821590-5mg 现货 ¥1058.00
    - +
    abs821590-50mg 现货 ¥4763.00
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    大包装询价
    产品描述
    描述
    Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.
    纯度
    ≥98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    地夸磷索四钠;INS365
    外观
    White to off-white crystalline powder
    可溶性/溶解性
    H2O : 100 mg/mL (113.87 mM; Need ultrasonic)
    DMSO : 1 mg/mL (1.14 mM; Need ultrasonic)
    生物活性
    In vitro(体外研究)
    Cell viability significantly decreased after treatment with 30% diluted diquafosol for 1 hour and 6 hours after treatment with 10% and 20% diluted diquafosol. Twenty-four hours after wounding monolayers, 3% diquafosol, and 0.3% HCECs exhibits significantly more wound healing than the control.
    In vivo(体内研究)
    In a rat dry eye model, the P2Y2 agonist diquafosol tetrasodium is found to improve surface health, based on increases in tear fluid secretion, corneal epithelial resistance, and release of glycoprotein-containing moieties from goblet cells. Beginning at 2 weeks and continuing for an additional 2 weeks, maximal declines in dye penetrance of approximately 50% occurred with doses of diquafosol tetrasodium as low as 1%. INS365 significantly suppresses corneal damage at concentrations of more than 0.1% w/v.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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