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  • Diphenyleneiodonium chloride

    • 二苯基氯化碘盐;氯化二亚苯基碘鎓;DPI
    货号: abs814816
    CAS号: 4673-26-1
    分子式: C12H8I•Cl
    分子量: 314.55
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    货号-规格 货期 价格 数量
    abs814816-25mg 1-2周 ¥1433.00
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    abs814816-100mg 1-2周 ¥3638.00
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    大包装询价
    产品描述
    描述

    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. 

    纯度
    ≥98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    形态
    Solid
    基本信息
    别名
    二苯基氯化碘盐;氯化二亚苯基碘鎓;DPI
    外观
    White to off-white solid
    可溶性/溶解性
    DMSO : 6 mg/mL (19.07 mM; Need ultrasonic and warming)
    生物活性
    靶点
    NOX
    In vitro(体外研究)
    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Application of Diphenyleneiodonium chloride to HEK-TRPA1 cells at a concentration ranges of 0.03 to 10 μM effectively induces a Ca2+ response. However, Diphenyleneiodonium chloride fails to evoke a Ca2+ response in control HEK cells, even at a relatively high dose of 10 μM. When Diphenyleneiodonium chloride is included in the co-cultures, lipopolysaccharide (LPS)-induced preOL apoptosis is significantly inhibited. Treatment with Diphenyleneiodonium chloride is found to significantly attenuate the LPS-induced O2- production by 2.0-fold, reducing it to within 27% of the controls.
    In vivo(体内研究)
    Intraplantar injection of 2 mM Diphenyleneiodonium chloride to the hindpaw causes licking or biting behavior. Diphenyleneiodonium chloride treatment immediately or 24 h after lipopolysaccharide (LPS) injection significantly attenuates the LPS-induced loss of O4 positive cells. Treatment with Diphenyleneiodonium chloride either immediately or 24 h after LPS injection significantly ameliorates the LPS-induced disorganization of the white matter nerve fibers. However, treatment with DPI 48 h after LPS injection does not appear to correct the LPS-induced white matter damage. DPI treatment either immediately or 24 h after LPS injection significantly reduces the accumulation of both gp91phox and p67phox in the membrane fraction.
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