3,3'-Diindolylmethane
- 3,3'-二吲哚甲烷;DIM;Arundine; HB 236
货号: abs811958
货号-规格 | 货期 | 价格 | 数量 |
abs811958-500mg | 1-2周 | ¥450.00 | - + |
abs811958-1g | 1-2周 | ¥650.00 | - + |

产品描述 | ||
描述 | DIM (3,3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 3,3'-二吲哚甲烷;DIM;Arundine; HB 236 | |
外观 | 白色至类白色结晶性粉末 | |
可溶性/溶解性 | DMSO : 24.6 mg/mL (100 mM) Ethanol : 18 mg/mL (73.08 mM) | |
生物活性 | ||
靶点 | Androgen Receptor | |
In vitro(体外研究) | DIM is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. DIM can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. DIM alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity. | |
In vivo(体内研究) | Preliminary studies show DIM is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of DIM has radioprotection and mitigation properties in vivo. DIM Activates ATM in Normal Tissues. DIM can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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