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  • 3,3'-Diindolylmethane
    • 3,3'-二吲哚甲烷;DIM;Arundine; HB 236
    货号: abs811958
    CAS号: 1968-05-4
    分子式: C17H14N2
    分子量: 246.31
    产品说明书
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    货号-规格 货期 价格 数量
    abs811958-100mg 1-2周 ¥510.00
    - +
    abs811958-500mg 1-2周 ¥789.00
    - +
    大包装询价
    产品描述
    描述

    DIM (3,3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent..

    纯度
    ≥99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    3,3'-二吲哚甲烷;DIM;Arundine; HB 236
    外观
    白色至类白色结晶性粉末
    可溶性/溶解性
    DMSO : 24.6 mg/mL (100 mM)

    Ethanol : 18 mg/mL (73.08 mM)
    生物活性
    靶点
    Androgen Receptor
    In vitro(体外研究)
    DIM is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. DIM can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. DIM alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity.
    In vivo(体内研究)
    Preliminary studies show DIM is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of DIM has radioprotection and mitigation properties in vivo. DIM Activates ATM in Normal Tissues. DIM can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability.
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