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  • Diciofenac

    • 双氯芬酸
    货号: abs816550
    CAS号: 15307-86-5
    分子式: C14H11Cl2NO2
    分子量: 296.15
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs816550-2mg 现货 ¥263.00
    - +
    abs816550-10mg 现货 ¥798.00
    - +
    abs816550-50mg 现货 ¥1596.00
    - +
    abs816550-100mg 现货 ¥2736.00
    - +
    大包装询价
    产品描述
    描述

    Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    双氯芬酸
    可溶性/溶解性
    DMSO : ≥ 3.5 mg/mL (11.82 mM)
    生物活性
    靶点
    COX
    In vitro(体外研究)
    Diclofenac is a potent COX inhibitor, with IC50s of 4 nM and 1.3 nM for human COX-1 and COX-2 in the CHO cells, respectively. Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7 ± 3 nM. Diclofenac sodium exihibits inhibition on COX-1 and COX-2 enzyme with IC50s of 5.1 and 0.84 μM, respectively.
    In vivo(体内研究)
    Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days. Diclofenac (10 mg/kg) shows anti-inflammatory activity in mice. Diclofenac (10 mg/kg) decreases oxidized low-densitylipoprotein (Ox-LDL), but shows no effects on the kinetics parameters of catalase and glutathione peroxidase via intramuscularly injection into rats.
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