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  • Deferoxamine Mesylate

    • 甲磺酸去铁胺;去铁铵
    货号: abs812898
    CAS号: 138-14-7
    分子式: C26H52N6O11S
    分子量: 656.79
    产品说明书
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    货号-规格 货期 价格 数量
    abs812898-50mg 1-2周 ¥386.00
    - +
    abs812898-100mg 现货 ¥475.00
    - +
    abs812898-500mg 1-2周 ¥1152.00
    - +
    abs812898-1g 1-2周 ¥2183.00
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    大包装询价
    产品描述
    描述

    Deferoxamine mesylate 是一种铁离子螯合剂,能够有效减少氧化应激和神经元的死亡。

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    甲磺酸去铁胺;去铁铵
    外观
    白色至类白色粉末
    可溶性/溶解性
    Water:10 mM
    生物活性
    靶点
    Mitophagy
    In vitro(体外研究)
    Deferoxamine treatment significantly increases HIF-1α binding under all culture conditions, including hypoxic and high-glucose. The mechanism of deferoxamine is through improving HIF-1α biological function through scavenging oxygen free radicals. Deferoxamine (5 μM) has significant effect on the tumor-associated stromal cells cellular multiplication, and cells die at day 7 after exposure to 50 μM and 100 μM deferoxamine. Deferoxamine (5 μM-100 μM) inhibits the proliferation of BMMSCs, and induces apoptosis of MSCs in a dose-dependent manner. Deferoxamine influences the expression of adhesion proteins on MSCs. Deferoxamine (30, 60, 120 μM) shows lower expression of HIF-1α in a concentration dependent way in AdMSCs.
    In vivo(体内研究)
    Deferoxamine (100 mg/kg, i.p.) lowers the mortality rate of subarachnoid hemorrhage (SAH) rat. Deferoxamine (100 mg/kg, i.p.) attenuates Evan’s blue extravasation in cortex, ameliorates the tight junction detachment and preserves the integrity of the base membrane examined in electron microscope at day 3 after SAH. Deferoxamine attenuates degradation of BBB proteins after SAH and significantly reduces ferritin expression at day 3 in the cortex, and improves neurologic behavior and cognitive deficits after experimental. Ten µL of 1 mM deferoxamine-treated wounds display significantly accelerated healing from day 7 onward and heal significantly faster than control-treated wounds in diabetic mice. Deferoxamine-treated wounds and dimethyloxalylglycine-treated wounds heal significantly faster than control-treated wounds in aged mice. In deferoxamine (10 mg/mL)-treated TG mice, there is a decrease in both soluble and insoluble Aβ40 and Aβ42. Both pGSK3β and β-catenin are significantly increased by approximately 50% in the deferoxamine-treated mice.
    参考文献
    参考文献
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