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  • Deferasirox

    • 地拉罗司;ICL 670
    货号: abs817234
    CAS号: 201530-41-8
    分子式: C21H15N3O4
    分子量: 373.36
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    货号-规格 货期 价格 数量
    abs817234-2mg 1-2周 ¥467.00
    - +
    abs817234-5mg 1-2周 ¥816.00
    - +
    abs817234-10mg 1-2周 ¥1469.00
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    大包装询价
    产品描述
    描述

    Deferasirox is an oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long term blood transfusions for conditions such as beta-thalassemia and other chronic anemias. It is the first oral medication approved in the USA for this purpose.

    纯度
    99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    地拉罗司;ICL 670
    外观
    白色至淡黄色性粉末
    可溶性/溶解性
    DMSO : 69 mg/mL (184.8 mM)

    Ethanol : 2 mg/mL (5.35 mM)
    生物活性
    靶点
    iron
    In vitro(体外研究)
    In LX-2 cells treated with 50 μM deferasirox for 12 h, α1(I)procollagen expression is decreased by 25%, with maximal reductions (10-fold) seen following 24-120 h of treatment. Similarly, α-smooth muscle actin (αSMA) expression is significantly lower. Deferasirox had anti-proliferative effects on HL-60 or KG-1 myeloid leukemia cell lines at a concentration as low as 5 μM . The cytotoxicity is both dose and time dependent. The viability of both EL4 cells and L1210 cells incubated with deferasirox decrease in a concentration-dependent manner.
    In vivo(体内研究)
    The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy.
    参考文献
    参考文献
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