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  • (D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P

    • [DArg1, DPhe5, DTrp7,9, Leu11] Substance P
    货号: abs45132046
    CAS号: 96736-12-8
    分子式: C79H109N19O12
    分子量: 1516.86
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    货号-规格 货期 价格 数量
    abs45132046-1mg 现货 ¥1229.00
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    abs45132046-5mg 4周 ¥4952.00
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    产品描述
    描述

     (D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P initially described as a low potency ghrelin receptor antagonist has surprisingly been found to be a full inverse agonist (EC50 = 5.2 nM). In COS-7 cells transiently transfected with the ghrelin receptor this substance P analog decreased the constitutive signaling down to levels observed in untransfected cells. Assuming that constitutive signaling of the ghrelin receptor is of physiological relevance in the regulation of appetite control, inverse agonists of the ghrelin receptor could be interesting for the treatment of obesity. So, Asakawa et al. found that peripherally administered L-0801-60 decreased food intake in lean mice, in mice with diet induced obesity, and in ob/ob obese mice.

    来源
    H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
    纯度
    95%
    储存/保存方法
    -20°C,有效期2年。
    基本信息
    别名
    [DArg1, DPhe5, DTrp7,9, Leu11] Substance P
    外观
    lyophilized powder
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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