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  • CWHM-12
    • CWHM 12,CWHM12
    货号: abs810092
    CAS号: 1564286-55-0
    分子式: C26H32BrN5O6
    分子量: 590.47
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810092-5mg 现货 ¥1820.00
    - +
    abs810092-10mg 1-2周 ¥2972.00
    - +
    abs810092-50mg 1-2周 ¥10835.00
    - +
    abs810092-100mg 1-2周 ¥15479.00
    - +
    大包装询价
    产品描述
    描述

    CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    CWHM 12,CWHM12
    外观
    Powder
    可溶性/溶解性
    DMSO: 10.5 mg/mL
    生物活性
    靶点
    Integrin
    In vitro(体外研究)
    CWHM-12 (CWHM 12) also less potently inhibits αvβ5 (IC50=61 nM) and αIIbβ3/α2β1/α10β1 (IC50>5000 nM). CWHM-12 demonstrates high potency against all of the five possible β subunit binding partners (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) in in vitro ligand-binding assays, with somewhat less potency against αvβ5 than against the other αv integrins.
    In vivo(体内研究)
    Mice are treated with CCl4 for 3 weeks to establish fibrotic disease and then treated with CWHM-12 (CWHM 12) or vehicle for the final 3 weeks of CCl4. CWHM-12 significantly reduces liver fibrosis even after fibrotic disease have been established. Digital image quantitation demonstrates significantly reduced p-SMAD3 signaling in the livers of CWHM-12 treated mice compare to controls, demonstrating that the protection from CCl4-induced hepatic fibrosis observed in CWHM-12 treated mice is due at least in part to a reduction in TGF-β activation by αv integrins. Besides, administration of CWHM-12 significantly inhibited progression of pulmonary fibrosis.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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