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  • (±)-CPSI-1306
  • CPSI-1306
  • 货号: abs820530
    CAS号: 1309793-47-2
    分子式: C15H16F2N2O3
    分子量: 310.30
    产品说明书
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    货号-规格 货期 价格 数量
    abs820530-5mg 4周 ¥2268.00
    - +
    abs820530-25mg 4周 ¥7371.00
    - +
    大包装询价
    产品描述
    描述

    (±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).

    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder)
    基本信息
    别名
    CPSI-1306
    可溶性/溶解性
    DMSO : 6 mg/mL (19.34 mM; Need ultrasonic)
    生物活性
    靶点
    MIF
    In vivo(体内研究)
    Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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