CPI-613
- CPI 613; CPI613
货号: abs812145
货号-规格 | 货期 | 价格 | 数量 |
abs812145-5mg | 1-2周 | ¥740.00 | - + |
abs812145-50mg | 1-2周 | ¥3851.00 | - + |

产品描述 | ||
描述 | CPI-613是一种Lipoate类似物,在NCI-H460 细胞系中抑制线粒体酶pyruvate dehydrogenase (PDH)和α-ketoglutarate dehydrogenase,干扰肿瘤细胞线粒体代谢。 | |
纯度 | 98% min | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | CPI 613; CPI613 | |
可溶性/溶解性 | DMSO 78 mg/mL warmed (200.72 mM) Ethanol 78 mg/mL (200.72 mM) Water Insoluble | |
生物活性 | ||
靶点 | PDH ,α-ketoglutarate dehydrogenase | |
In vitro(体外研究) | In vitro, CPI-613 produces the selective toxicity against several tumor cell lines including H460 human lung cancer cells and Saos-2 human sarcoma cells with EC50 of 120 μM and 120 μM, respectively. CPI-613 disrupts H460 cancer cell mitochondrial metabolism including inhibition of PDH complex activity and loss of mitochondrial membrane potential in a time- and drug dose-dependent fashion. In addition, CPI-613 (240 μM) also induces both apoptotic and non-apoptotic cell death in H460 human lung cancer and Saos-2 human sarcoma cells. | |
In vivo(体内研究) | CPI-613 (25 mg/kg) has potent anticancer activity in a human tumor xenograft model of of a pancreatic tumor cell (BxPC-3). Similarly, CPI-613 (10 mg/kg) also produces significant tumor growth inhibition of H460 human non-small cell lung carcinoma in mouse model. Besides, CPI-613 produces little or no side-effect toxicity in expected therapeutic dose ranges in large animal models and has the maximum tolerated dose of 100 mg/kg in mice. | |
参考文献 | ||
参考文献 | [1] Zachar Z, et al. J Mol Med (Berl). 2011, 89(11), 1137-1148. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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