首页 产品中心
  • CPI-613
  • CPI 613; CPI613
  • 货号: abs812145
    CAS号: 95809-78-2
    分子式: C22H28O2S2
    分子量: 388.59
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs812145-5mg 1-2周 ¥705.00
    - +
    abs812145-50mg 1-2周 ¥3668.00
    - +
    大包装询价
    产品描述
    描述

    CPI-613是一种Lipoate类似物,在NCI-H460 细胞系中抑制线粒体酶pyruvate dehydrogenase (PDH)和α-ketoglutarate dehydrogenase,干扰肿瘤细胞线粒体代谢。

    纯度
    98% min
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    CPI 613; CPI613
    可溶性/溶解性
    DMSO 78 mg/mL warmed (200.72 mM)

    Ethanol 78 mg/mL (200.72 mM)

    Water Insoluble
    生物活性
    靶点
    PDH ,α-ketoglutarate dehydrogenase
    In vitro(体外研究)
    In vitro, CPI-613 produces the selective toxicity against several tumor cell lines including H460 human lung cancer cells and Saos-2 human sarcoma cells with EC50 of 120 μM and 120 μM, respectively. CPI-613 disrupts H460 cancer cell mitochondrial metabolism including inhibition of PDH complex activity and loss of mitochondrial membrane potential in a time- and drug dose-dependent fashion. In addition, CPI-613 (240 μM) also induces both apoptotic and non-apoptotic cell death in H460 human lung cancer and Saos-2 human sarcoma cells.
    In vivo(体内研究)
    CPI-613 (25 mg/kg) has potent anticancer activity in a human tumor xenograft model of of a pancreatic tumor cell (BxPC-3). Similarly, CPI-613 (10 mg/kg) also produces significant tumor growth inhibition of H460 human non-small cell lung carcinoma in mouse model. Besides, CPI-613 produces little or no side-effect toxicity in expected therapeutic dose ranges in large animal models and has the maximum tolerated dose of 100 mg/kg in mice.
    参考文献
    参考文献
    [1] Zachar Z, et al. J Mol Med (Berl). 2011, 89(11), 1137-1148.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
        提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
        提交不成功?请联系info@absin.cn。
        我要提问

    促销资讯 更多

      订购信息
      您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
      GO
      • 0