CPI-1205
- CPI 1205, CPI1205
货号: abs812275
货号-规格 | 货期 | 价格 | 数量 |
abs812275-5mg | 1-2周 | ¥2122.00 | - + |
abs812275-10mg | 1-2周 | ¥3614.00 | - + |

产品描述 | ||
描述 | CPI-1205是一种有效的选择性组蛋白赖氨酸甲基转移酶EZH2的抑制剂,具有潜在的抗肿瘤活性。 | |
纯度 | 98% min | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | CPI 1205, CPI1205 | |
可溶性/溶解性 | DMSO 100 mg/mL (192.83 mM) Ethanol 100 mg/mL (192.83 mM) Water slightly soluble or insoluble | |
生物活性 | ||
靶点 | EZH2 ,EZH1 | |
In vitro(体外研究) | Treatment with EZH2 inhibitor CPI-1205 cause apoptosis in multiple myeloma and plasmacytoma cell models. | |
In vivo(体内研究) | CPI-1205 shows excellent oral bioavailability. It was well-tolerated for repeat dosing as demonstrated by the absence of significant body weight loss. CPI-1205 shows relatively high clearance in both rats and dogs (3.19 L/h/kg and 1.41 L/h/kg, respectively) but demonstrates good oral bioavailability in both species(44.6% F in rats and 46.2% F in dogs). CPI-1205 was well-tolerated in the 28-day GLP toxicology studies, and any findings were reversible over the recovery period. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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