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  • Clinofibrate

    • 克利贝特
    货号: abs816374
    CAS号: 30299-08-2
    分子式: C28H36O6
    分子量: 468.58
    产品说明书
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    货号-规格 货期 价格 数量
    abs816374-5mg 1-2周 ¥601.00
    - +
    abs816374-10mg 1-2周 ¥849.00
    - +
    abs816374-50mg 1-2周 ¥2814.00
    - +
    abs816374-100mg 1-2周 ¥5065.00
    - +
    大包装询价
    产品描述
    描述

    Clinofibrate抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)(羟甲基戊二酰辅酶A还原酶),IC50为0.47 mM,是一种降脂剂,用于控制血液中的高胆固醇和甘油三酯水平。Clinofibrate是降低血脂药物,IC50为40μM,作用于人类肝脏3α-羟类固醇脱氢酶的活性。Clinofibrate刺激AKR 1C4的活性达2倍。Clinofibrate 最高刺激浓度达50 μM。

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    克利贝特
    外观
    白色粉末
    可溶性/溶解性
    Ethanol :87 mg/mL (185.7 mM)

    DMSO :87 mg/mL (185.7 mM)
    生物活性
    靶点
    HMGCR
    In vitro(体外研究)
    Clinofibrate is an antihyperlipidemic agent with IC50 with 40 μM on the activities of human liver 3α-hydroxysteroid dehydrogenases. Clinofibrate stimulates the activity of AKR 1C4 by 2.0-fold. The concentration of Clinofibrate at which maximum stimulation is achieved is 50 μM.
    In vivo(体内研究)
    Clinofibrate significantly decreases the high plasma cholesterol level of atherosclerotic rats, which is 823 +/- 256 (mean +/- SD) mg/dl, or about ten times that of control rats (85 +/- 11 mg/dl). On treatment with Clinofibrate, the cholesterol level is reduced mostly in the very low density lipoprotein (VLDL) fraction (d less than 1.006). Heparin-releasable lipoprotein lipase activity in epididymal adipose tissue, lipoprotein lipase activity in post heparin plasma, and VLDL-triolein hydrolizing activity in adipose tissue stromal vessels are higher in Clinofibrate-treated rats than in atherosclerotic rats. Of the enzymes in the arterial wall concerned with cholesterol ester metabolism, acid cholesterol esterase activity is decreased in atherosclerotic rats, and Clinofibrate treatment increased this activity. The ratio of acyl-CoA cholesterol acyltransferase activity (ACAT) to neutral cholesterol esterase activity is higher in atherosclerotic rats than in control rats and is lower in Clinofibrate-treated rats than in atherosclerotic rats.
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