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  • Cimetropium Bromide

    • 西托溴铵;DA-3177
    货号: abs822247
    CAS号: 51598-60-8
    分子式: C21H28BrNO4
    分子量: 438.36
    产品说明书
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    货号-规格 货期 价格 数量
    abs822247-1mg 1-2周 ¥1323.00
    - +
    abs822247-5mg 1-2周 ¥2646.00
    - +
    大包装询价
    产品描述
    描述
    Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome.
    纯度
    96%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    西托溴铵;DA-3177
    可溶性/溶解性
    H2O : 50 mg/mL (114.06 mM; Need ultrasonic)
    生物活性
    靶点
    mAChR
    In vitro(体外研究)
    Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82. Cimetropium has potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. In the superfusion experiments of the preparation which has been preloaded with labelled choline, Cimetropium decreases the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition.
    In vivo(体内研究)
    When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID50 of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension.
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    • 实验方法 实验条件
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