CH5138303
货号： abs817764
| 货号-规格 | 货期 | 价格 | 数量 |
| abs817764-1mg | 1-2周 | ￥776.00 | - + |
| abs817764-5mg | 1-2周 | ￥2648.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. | |
| 纯度 | 98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 可溶性/溶解性 | DMSO:83 mg/mL (199.56 mM) | |
| 生物活性 | ||
| 靶点 | HSP90α | |
| In vitro(体外研究) | CH5138303 shows high affinity to Hsp90αand potent cell growth inhibitory activity against an HCT116 colorectal cancer cell line and an NCI-N87 gastric cancer cell line with IC50 of 98 nM and 66 nM, respectively. Besides, CH5138303 also demonstrates liver microsomal stability. | |
| In vivo(体内研究) | CH5138303 (50 mg/kg p.o.) displays high oral bioavailability in mice and produces potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model. | |
| 参考文献 | ||
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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Certificate of Analysis(COA)
