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  • CFTR Inhibitor II, GlyH-101
  • GlyH-101,Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II,GlyH 101; GlyH101
  • 货号: abs810614
    CAS号: 328541-79-3
    分子式: C19H15Br2N3O3
    分子量: 493.15
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810614-5mg 1-2周 ¥968.00
    - +
    abs810614-10mg 1-2周 ¥1704.00
    - +
    abs810614-50mg 1-2周 ¥6711.00
    - +
    abs810614-100mg 1-2周 ¥12285.00
    - +
    大包装询价
    产品描述
    描述

    CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 μM; Ki = 4.3 μM in CFTR-expressing FRT cells.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
    基本信息
    别名
    GlyH-101,Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II,GlyH 101; GlyH101
    外观
    Solid powder
    可溶性/溶解性
    DMSO : 49.3 mg/mL (100 mM)
    生物活性
    靶点
    CFTR
    In vitro(体外研究)
    GlyH-101 reversibly inhibits CFTR Cl- conductance in In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents.
    In vivo(体内研究)
    In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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