GlyH-101
- GlyH-101，Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II,GlyH 101; GlyH101
货号： abs810614
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810614-10mg | 1-2周 | ￥1115.00 | - + |
| abs810614-50mg | 1-2周 | ￥3345.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 μM; Ki = 4.3 μM in CFTR-expressing FRT cells. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | GlyH-101，Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II,GlyH 101; GlyH101 | |
| 外观 | Solid powder | |
| 可溶性/溶解性 | DMSO : 49.3 mg/mL (100 mM)
| |
| 生物活性 | ||
| 靶点 | CFTR | |
| In vitro(体外研究) | GlyH-101 reversibly inhibits CFTR Cl- conductance in In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. | |
| In vivo(体内研究) | In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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