CEP-40783
- RXDX-106
货号: abs814622
货号-规格 | 货期 | 价格 | 数量 |
abs814622-5mg | 1-2周 | ¥1268.00 | - + |
abs814622-25mg | 1-2周 | ¥4366.00 | - + |

产品描述 | ||
描述 | RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | RXDX-106 | |
外观 | powder | |
可溶性/溶解性 | DMSO : 7.6 mg/mL (12.91 mM; Need ultrasonic and warming) | |
生物活性 | ||
靶点 | Axl,c-Met,Tyro3,MER | |
In vitro(体外研究) | RXDX-106 inhibits TAM and c-MET phosphorylation in vitro. This inhibition of TAM and c-MET activation in vitro is accompanied by a decrease in downstream MAPK and PI3K signaling and cell viability. It completely inhibits cellular proliferation and viability at sub-nanomolar concentrations in TAM-expressing cells. | |
In vivo(体内研究) | RXDX-106 could inhibit tumors harboring activating TAM gene fusions and affect the TAM-expressing tumor microenvironment to result in a global anti-cancer environment. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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