CEP-40783
- RXDX-106
货号： abs814622
| 货号-规格 | 货期 | 价格 | 数量 |
| abs814622-5mg | 1-2周 | ￥1268.00 | - + |
| abs814622-25mg | 1-2周 | ￥4366.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. | |
| 纯度 | ＞98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | RXDX-106 | |
| 外观 | powder | |
| 可溶性/溶解性 | DMSO : 7.6 mg/mL (12.91 mM; Need ultrasonic and warming) | |
| 生物活性 | ||
| 靶点 | Axl,c-Met,Tyro3,MER | |
| In vitro(体外研究) | RXDX-106 inhibits TAM and c-MET phosphorylation in vitro. This inhibition of TAM and c-MET activation in vitro is accompanied by a decrease in downstream MAPK and PI3K signaling and cell viability. It completely inhibits cellular proliferation and viability at sub-nanomolar concentrations in TAM-expressing cells. | |
| In vivo(体内研究) | RXDX-106 could inhibit tumors harboring activating TAM gene fusions and affect the TAM-expressing tumor microenvironment to result in a global anti-cancer environment. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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危险品化学品经营许可证(不带存储) 许可证编号：沪(浦)应急管危经许[2022]202585(YS)
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