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  • Cenicriviroc
    • TAK-652; TBR-652; TAK652; TBR652; TAK 652; TBR 652
    货号: abs811377
    CAS号: 497223-25-3
    分子式: C41H52N4O4S
    分子量: 696.94
    产品说明书
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    货号-规格 货期 价格 数量
    abs811377-10mg 1-2周 ¥4410.00
    - +
    abs811377-50mg 1-2周 ¥11907.00
    - +
    大包装询价
    产品描述
    描述

    Cenicriviroc is an experimental drug candidate for the treatment of HIV infection.Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    TAK-652; TBR-652; TAK652; TBR652; TAK 652; TBR 652
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    HIV
    In vitro(体外研究)
    Cenicriviroc prevents human immunodeficiency virus type 1 (HIV-1) from cellular entry. Regarding the 4 R5 HIV-2 clinical isolates tested, effective concentration 50% EC50 for cenicriviroc are 0.03, 0.33, 0.45 and 0.98 nM. The dual-tropic and the X4-tropic HIV-2 strains are resistant to cenicriviroc with EC50 at >1000 nM, and MPI at 33% and 4%, respectively.
    In vivo(体内研究)
    Cenicriviroc (≥20 mg/kg/day) significantly reduces monocyte/macrophage recruitment in vivo. At these doses, cenicriviroc shows antifibrotic effects, with significant reductions in collagen deposition, and collagen type 1 protein and mRNA expression across the three animal models of fibrosis. In the NASH model, cenicriviroc significantly reduces the non-alcoholic fatty liver disease activity score. Cenicriviroc treatment has no notable effect on body or liver/kidney weight.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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