Celocoxib
- 塞来昔布;Celebra;Celebrex;SC 58635
货号: abs812001
货号-规格 | 货期 | 价格 | 数量 |
abs812001-100mg | 1-2周 | ¥794.00 | - + |
abs812001-1g | 现货 | ¥2361.00 | - + |

产品描述 | ||
描述 | Celecoxib是一种选择性COX-2抑制剂,在Sf9细胞中IC50为40 nM。 | |
应用 | A selective Cox-2 inhibitor | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 塞来昔布;Celebra;Celebrex;SC 58635 | |
外观 | 白色至类白色粉末 | |
可溶性/溶解性 | DMSO : 71 mg/mL (186.2 mM) Ethanol : 31 mg/mL (81.3 mM) | |
生物活性 | ||
靶点 | COX-2 | |
In vitro(体外研究) | Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. | |
In vivo(体内研究) | Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). | |
参考文献 | ||
参考文献 | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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