首页 产品中心
  • CDDO-EA
  • 货号: abs818407
    CAS号: 932730-51-3
    分子式: C33H46N2O3
    分子量: 518.73
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs818407-2mg 1-2周 ¥2172.00
    - +
    abs818407-5mg 1-2周 ¥5880.00
    - +
    大包装询价
    产品描述
    描述
    CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    Keap1-Nrf2
    In vitro(体外研究)
    CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
    In vivo(体内研究)
    The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
        提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
        提交不成功?请联系info@absin.cn。
        我要提问

    促销资讯 更多

      订购信息
      您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
      GO
      • 0