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  • CC-930

    • Tanzisertib;CC 930;CC930
    货号: abs811371
    CAS号: 899805-25-5
    分子式: C21H23F3N6O2
    分子量: 448.44
    产品说明书
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    货号-规格 货期 价格 数量
    abs811371-5mg 1-2周 ¥2205.00
    - +
    abs811371-10mg 1-2周 ¥3308.00
    - +
    大包装询价
    产品描述
    描述

    CC-930 is a selective c-Jun amino-terminal kinase (JNK) inhibitor and is currently under clinical development for fibrotic and infammatory indications.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Tanzisertib;CC 930;CC930
    外观
    Powder
    可溶性/溶解性
    DMSO : ≥ 33 mg/mL (73.59 mM)
    生物活性
    靶点
    JNK1,JNK2,JNK3
    In vitro(体外研究)
    Tanzisertib (CC-930) inhibits the formation of phospho-cJun in human PBMC stimulated by phorbol-12-myristate-13-acetate and phytohemeagglutinin (IC50=1 μM). Tanzisertib (CC-930) (1-2 μM) substantially reduces hepatocyte apoptosis and necrosis, abrogates apoptosis and necrosis in FC-loaded WT hepatocytes. Tanzisertib (CC-930) blocks the JNK pathway that is activated by pro-fibrotic cytokines in systemic sclerosis.
    In vivo(体内研究)
    CC-930 (10 and 30 mg/kg, p.o.) inhibits the production of TNFa by 23% and 77% in the acute rat LPS-induced TNFa production PK-PD model. CC-930 (150 mg/kg) prevents the development of fibrosis in different models, but can also induce the regression of pre-existing fibrosis.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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