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  • (S)-Caspase-3/7 Inhibitor I
  • 5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
  • 货号: abs814634
    CAS号: 220509-74-0
    分子式: C14H16N2O5S
    分子量: 324.4
    产品说明书
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    货号-规格 货期 价格 数量
    abs814634-1mg 1-2周 ¥1607.00
    - +
    abs814634-10mg 1-2周 ¥7088.00
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    大包装询价
    产品描述
    描述

    Caspase-3/7 inbibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 mM). It Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. It has been shown to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 µM). Also it has been reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). Selectivity for caspases-3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. In some systems inhibition of caspases-3 and -7 can prevent apoptosis and may therefore have important therapeutic implications. 

    纯度
    98%
    储存/保存方法
    Store at -20° C
    基本信息
    别名
    5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
    外观
    Yellow solid
    密度
    1.42 g/cm3 (Predicted)
    熔点
    228.25° C (Predicted)
    沸点
    533.50° C (Predicted)
    折射率
    n20D 1.60 (Predicted)
    IC50
    caspase-7: IC50 = 170 nM (human); caspase-3: IC50 = 84.9 nM (human); apoptosis: IC50 = ~50 µM (camptothecin treated Jurkat cells)
    PK值
    pKa: 8.66 (Predicted)
    Ki 数据
    Caspase-9: Ki= 1100 nM (human); caspase-7: Ki= 170 nM; caspase-3: Ki= 60 nM
    可溶性/溶解性
    DMSO :≥16.2mg/mL
    MDL
    MFCD22581511
    PubChem CID
    9840223
    生物活性
    靶点
    Caspase-3,Caspase-7
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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