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  • Carprofen

    • 卡洛芬
    货号: abs813541
    CAS号: 53716-49-7
    分子式: C15H12ClNO2
    分子量: 273.71
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs813541-25mg 现货 ¥386.00
    - +
    abs813541-50mg 现货 ¥503.00
    - +
    abs813541-100mg 现货 ¥641.00
    - +
    abs813541-200mg 1-2周 ¥852.00
    - +
    大包装询价
    产品描述
    描述

    Carprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    卡洛芬
    外观
    White to white crystalline powder
    可溶性/溶解性
    DMSO : 100 mg/mL (365.35 mM; Need ultrasonic)
    生物活性
    靶点
    FAAH
    In vitro(体外研究)
    Carprofen (Compound 1) is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively. Carprofen (10 µg/mL) shows cytoprotective effects in CCL and CaCL cells and decreases apoptosis of both cells. Carprofen (10 µg/mL) exhibits nonsignificant increase in PGE2 concentration, compared with that of the respective CCL or CaCL controls.
    In vivo(体内研究)
    Carprofen (2.2 mg/kg, p.o.) significantly decreases PGE2 concentration in blood of dogs on days 3 and 10. Carprofen also decreases amounts of gastric PGE2 synthesis on day 3, but the inhibition is not obvious on day 10. In addition, Carprofen shows no activity against gastric PGE1 synthesis in dogs on day 3 and 10.
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