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  • CAPADENOSON

    • BAY 68-4986
    货号: abs811488
    CAS号: 544417-40-5
    分子式: C25H18ClN5O2S2
    分子量: 520
    产品说明书
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    货号-规格 货期 价格 数量
    abs811488-5mg 1-2周 ¥3226.00
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    abs811488-10mg 1-2周 ¥4162.00
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    大包装询价
    产品描述
    描述

    Capadenoson  is a new adenosine A1 receptor agonist.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    BAY 68-4986
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    Adenosine Receptor
    In vitro(体外研究)
    To further elucidate the pharmacological properties of Capadenson, GTP shift assays are performed with the standard full A1-agonist CCPA and the A1-antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX). CCPA shows a Ki value of 4.2 nM in the binding assay on rat cortical brain membranes. In the presence of 1 mM GTP this Ki value shifts to a value of 64 nM. Therefore the GTP shift for CCPA is 15. DPCPX shows a GTP shift of 1 with virtually identical Ki values in the absence and presence of GTP. Capadenson shows a Ki value of 24 nM in the binding assay. In the presence of 1 mM GTP this Ki value shifts to a value of 116 nM resulting in a GTP shift of 5 for Capadenoson.
    In vivo(体内研究)
    In the in vivo experiments, Wistar rats and SHR are pre-treated with Capadenoson at a concentration of 0.15 mg/kg for 5 days. On day 5, a stress test (physical restraint) is performed for 2 hours. The plasma concentration of Capadenoson measured 3 hours after drug intake remains constant in the 5 days prior to the restraint stress test and averaged 7.63 µg/L on day 4 and 5, respectively.
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    • 实验方法 实验条件
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