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  • Campathecin
  • 喜树碱;Camptothecin;(S)-(+)-Camptothecin; CPT
  • 货号: abs818814
    CAS号: 7689-03-4
    分子式: C20H16N2O4
    分子量: 348.35
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs818814-50mg 1-2周 ¥362.00
    - +
    abs818814-100mg 1-2周 ¥397.00
    - +
    abs818814-200mg 1-2周 ¥715.00
    - +
    abs818814-500mg 1-2周 ¥1446.00
    - +
    大包装询价
    产品描述
    描述

    An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    喜树碱;Camptothecin;(S)-(+)-Camptothecin; CPT
    外观
    淡黄色结晶性粉末
    可溶性/溶解性
    DMSO : 3 mg/mL (8.61 mM)
    生物活性
    靶点
    Topo I
    In vivo(体内研究)
    [3H]BrCPT labeling of topoisomerase I is enhanced greatly by the presence of DNA; very little labeling of isolated topoisomerase I or isolated DNA occurrs. Even in the presence of DNA, [3H]BrCPT labeling of topoisomerase I is inhibited by camptothecin, suggesting that both CPT and BrCPT bind to the same site on the DNA-topoisomerase I binary complex. With increasing concentrations of camptothecin, closed circular pRR322 DNA (form I) is converted to nicked circular DNA (form 11). This apparent nicking activitv of camptothecin required DNA topoisomerase I.
    参考文献
    参考文献
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