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  • BX-795
    • BX 795; BX-795
    货号: abs810349
    CAS号: 702675-74-9
    分子式: C23H26IN7O2S
    分子量: 591.47
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810349-5mg 现货 ¥631.00
    - +
    abs810349-10mg 现货 ¥1176.00
    - +
    abs810349-50mg 现货 ¥4233.00
    - +
    abs810349-100mg 现货 ¥6743.00
    - +
    大包装询价
    产品描述
    描述

    BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM respectively; > 50 fold selectivity over PKA, PKC, c-Kit, GSK3β etc.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    BX 795; BX-795
    外观
    white to light brown powder
    可溶性/溶解性
    Ethanol :59.2 mg/mL (100 mM)
    DMSO :59.2 mg/mL (100 mM)
    生物活性
    靶点
    PDK-1
    In vitro(体外研究)
    BX795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. In addition, BX795, as an inhibitor of the TBK1/IKKε, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. 
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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