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  • 2,3-Butanedione 2-Monoxime
    • 2,3-丁烷二酮一肟;二乙酰一肟;NSC 660;NSC 116103
    货号: abs817423
    CAS号: 57-71-6
    分子式: C25H52NO4P
    分子量: 461.66
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs817423-25mg 1-2周 ¥431.00
    - +
    abs817423-50mg 1-2周 ¥639.00
    - +
    abs817423-100mg 1-2周 ¥776.00
    - +
    abs817423-200mg 1-2周 ¥1397.00
    - +
    大包装询价
    产品描述
    描述
    2,3-Butanedione 2-Monoxime is an inhibitor of skeletal and cardiac muscle contraction.
    纯度
    >99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    2,3-丁烷二酮一肟;二乙酰一肟;NSC 660;NSC 116103
    外观
    白色至类白色结晶性粉末
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    skeletal muscle myosin-II
    In vitro(体外研究)
    BDM inhibits skeletal muscle myosin-II, but it does not inhibit the ATPase activity of the other myosins. BDM has a broad effect on many non-myosin proteins (many uncharacterized), and thus should not be used in whole-cell experiments as a myosin inhibitor. BDM inhibits the L-type Ca2+-channel and reduces the opening probability, thereby increasing the closed time of this particular channel. BDM drives nonspecific protein dephosphorylation of many cellular proteins, including ion channels.
    In vivo(体内研究)
    BDM significant lowers the blood pressure in normo- and hypertensive rats. BDM has been shown to improve right atrial function in a porcine model of allogenic heart transplantation.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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