2,3-Butanedione 2-Monoxime
- 2,3-丁烷二酮一肟;二乙酰一肟;NSC 660;NSC 116103
货号: abs817423
货号-规格 | 货期 | 价格 | 数量 |
abs817423-25mg | 现货 | ¥185.00 | - + |
abs817423-50mg | 现货 | ¥245.00 | - + |
abs817423-100mg | 现货 | ¥315.00 | - + |
abs817423-200mg | 现货 | ¥425.00 | - + |

产品描述 | ||
描述 | 2,3-Butanedione 2-Monoxime is an inhibitor of skeletal and cardiac muscle contraction. | |
纯度 | >99% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 2,3-丁烷二酮一肟;二乙酰一肟;NSC 660;NSC 116103
| |
外观 | 白色至类白色结晶性粉末 | |
可溶性/溶解性 | 10 mM in DMSO | |
生物活性 | ||
靶点 | skeletal muscle myosin-II | |
In vitro(体外研究) | BDM inhibits skeletal muscle myosin-II, but it does not inhibit the ATPase activity of the other myosins. BDM has a broad effect on many non-myosin proteins (many uncharacterized), and thus should not be used in whole-cell experiments as a myosin inhibitor. BDM inhibits the L-type Ca2+-channel and reduces the opening probability, thereby increasing the closed time of this particular channel. BDM drives nonspecific protein dephosphorylation of many cellular proteins, including ion channels. | |
In vivo(体内研究) | BDM significant lowers the blood pressure in normo- and hypertensive rats. BDM has been shown to improve right atrial function in a porcine model of allogenic heart transplantation. | |
参考文献 | ||
参考文献 | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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