2,3-Butanedione 2-Monoxime
- 2,3-丁烷二酮一肟；二乙酰一肟；NSC 660；NSC 116103
货号： abs817423
| 货号-规格 | 货期 | 价格 | 数量 |
| abs817423-25mg | 现货 | ￥185.00 | - + |
| abs817423-50mg | 现货 | ￥245.00 | - + |
| abs817423-100mg | 现货 | ￥315.00 | - + |
| abs817423-200mg | 现货 | ￥425.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | 2,3-Butanedione 2-Monoxime is an inhibitor of skeletal and cardiac muscle contraction. | |
| 纯度 | ＞99% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | 2,3-丁烷二酮一肟；二乙酰一肟；NSC 660；NSC 116103
| |
| 外观 | 白色至类白色结晶性粉末 | |
| 可溶性/溶解性 | 10 mM in DMSO | |
| 生物活性 | ||
| 靶点 | skeletal muscle myosin-II | |
| In vitro(体外研究) | BDM inhibits skeletal muscle myosin-II, but it does not inhibit the ATPase activity of the other myosins. BDM has a broad effect on many non-myosin proteins (many uncharacterized), and thus should not be used in whole-cell experiments as a myosin inhibitor. BDM inhibits the L-type Ca2+-channel and reduces the opening probability, thereby increasing the closed time of this particular channel. BDM drives nonspecific protein dephosphorylation of many cellular proteins, including ion channels. | |
| In vivo(体内研究) | BDM significant lowers the blood pressure in normo- and hypertensive rats. BDM has been shown to improve right atrial function in a porcine model of allogenic heart transplantation. | |
| 参考文献 | ||
| 参考文献 | ||
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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