BQ-123
货号: abs816163
货号-规格 | 货期 | 价格 | 数量 |
abs816163-1mg | 现货 | ¥1546.00 | - + |
abs816163-5mg | 现货 | ¥5703.00 | - + |

产品描述 | ||
描述 | BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
外观 | powder | |
可溶性/溶解性 | DMSO : ≥ 34 mg/mL (55.67 mM) | |
生物活性 | ||
靶点 | Endothelin A receptor | |
In vitro(体外研究) | In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibits ETA-mediated contraction. In rat vascular smooth muscle cells, BQ-123 inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis. | |
In vivo(体内研究) | In rats, BQ-123 (1 mg/kg, i.v.) ameliorates myocardial ischemic-reperfusion injury. In rats with pentylenetetrazole (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, i.v.) potently impedes the formation and spread of seizure. In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, i.p.) prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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