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  • Bovinocidin

    • 3-硝基丙酸;β-Nitropropionic acid;Bovinocidin
    货号: abs817688
    CAS号: 504-88-1
    分子式: C3H5NO4
    分子量: 119.08
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs817688-25mg 1-2周 ¥419.00
    - +
    abs817688-50mg 1-2周 ¥529.00
    - +
    abs817688-100mg 1-2周 ¥560.00
    - +
    abs817688-200mg 1-2周 ¥840.00
    - +
    大包装询价
    产品描述
    描述
    Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
    纯度
    99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    3-硝基丙酸;β-Nitropropionic acid;Bovinocidin
    外观
    白色结晶
    可溶性/溶解性
    DMSO : ≥ 130 mg/mL (1091.70 mM)
    生物活性
    靶点
    Succinate dehydrogenase
    In vitro(体外研究)
    3-nitropropionic acid (3-NPA) is an irreversible inhibitor of complex II in the mitochondria. It impairs cellular energy metabolism via inhibition of succinate dehydrogenase, which induces a reduction in ATP production and leads to oxidative stress. 3-NPA can cause the generation and release of ROS from mitochondria, mitochondrial DNA damage, and thus loss of mitochondrial function. 3-NPA reduces the number of large follicles, impairs oocyte development, and increases the percentage of atretic large follicles and ROS levels in oocytes and granulosa cells. ROS production followed by mitochondrial DNA damage is the primary event in 3-NPA toxicity, and Bcl-2 protects PC12 cells from 3-NPA toxicity by preventing mitochondrial DNA damage.
    In vivo(体内研究)
    3-NPA induces granulosa cell apoptosis, large follicle atresia, and an increase of ROS levels in the ovary.
    参考文献
    参考文献
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