Rimegepant
- 瑞美吉泮, BMS-927711;BMS 927711
货号: abs811269
货号-规格 | 货期 | 价格 | 数量 |
abs811269-10mg | 1-2周 | ¥2450.00 | - + |
abs811269-50mg | 1-2周 | ¥8819.00 | - + |

产品描述 | ||
描述 | Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM and an IC50 of 0.14 nM for hCGRP receptor. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 瑞美吉泮; BMS-927711;BMS 927711 | |
可溶性/溶解性 | DMSO : 10 mg/mL (18.71 mM; Need ultrasonic and warming) | |
生物活性 | ||
靶点 | CGRP Receptor | |
In vitro(体外研究) | BMS-927711 is a full, competitive CGRP receptor antagonist with IC50 of 0.14±0.01 nM. | |
In vivo(体内研究) | BMS-927711 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, and shows dose-dependent activity in a primate model of CGRP-induced facial blood flow. The ratios of the mean AUC (0-24 h) values for BMS-927711 (60, 100, and 300 mg/kg) in the DBS matrix, compare with plasma, are 0.5-0.6 across all doses in rats. Results from this study suggest a strong correlation of BMS-927711 concentrations between rat plasma and rat blood (DBS). | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
共 0 张,还能上传 8 张 提交
- 提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要咨询”按钮填写您的疑问。
提交不成功?请联系info@absin.cn。
促销资讯 更多
订购信息
您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。