Rimegepant
- 瑞美吉泮, BMS-927711；BMS 927711
货号： abs811269
| 货号-规格 | 货期 | 价格 | 数量 |
| abs811269-10mg | 1-2周 | ￥2450.00 | - + |
| abs811269-50mg | 1-2周 | ￥8819.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM and an IC50 of 0.14 nM for hCGRP receptor. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | 瑞美吉泮; BMS-927711；BMS 927711 | |
| 可溶性/溶解性 | DMSO : 10 mg/mL (18.71 mM; Need ultrasonic and warming) | |
| 生物活性 | ||
| 靶点 | CGRP Receptor | |
| In vitro(体外研究) | BMS-927711 is a full, competitive CGRP receptor antagonist with IC50 of 0.14±0.01 nM. | |
| In vivo(体内研究) | BMS-927711 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, and shows dose-dependent activity in a primate model of CGRP-induced facial blood flow. The ratios of the mean AUC (0-24 h) values for BMS-927711 (60, 100, and 300 mg/kg) in the DBS matrix, compare with plasma, are 0.5-0.6 across all doses in rats. Results from this study suggest a strong correlation of BMS-927711 concentrations between rat plasma and rat blood (DBS). | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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