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  • BMS-303141
  • BMS303141; BMS 303141
  • 货号: abs810661
    CAS号: 943962-47-8
    分子式: C19H15Cl2NO4S
    分子量: 424.3
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810661-5mg 1-2周 ¥688.00
    - +
    abs810661-10mg 1-2周 ¥888.00
    - +
    abs810661-50mg 1-2周 ¥3166.00
    - +
    abs810661-100mg 1-2周 ¥5698.00
    - +
    大包装询价
    产品描述
    描述
    BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor with IC50 value of 0.13 uM (human recombinant ACL).
    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
    基本信息
    别名
    BMS303141; BMS 303141
    外观
    Powder
    可溶性/溶解性
    DMSO: ≥ 47 mg/mL
    生物活性
    靶点
    ATP Citrate Lyase
    In vitro(体外研究)
    In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity.
    In vivo(体内研究)
    Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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