BLU-554
- BLU-554
货号: abs818293
货号-规格 | 货期 | 价格 | 数量 |
abs818293-1mg | 1-2周 | ¥650.00 | - + |
abs818293-5mg | 1-2周 | ¥1350.00 | - + |
abs818293-10mg | 1-2周 | ¥2150.00 | - + |
abs818293-50mg | 1-2周 | ¥6150.00 | - + |

产品描述 | ||
描述 | Fisogatinib (BLU-554) is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | BLU-554 | |
可溶性/溶解性 | DMSO : 100 mg/mL (198.66 mM; Need ultrasonic) | |
生物活性 | ||
靶点 | FGFR | |
In vitro(体外研究) | Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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