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  • BIO

    • 6BIO; 6-BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052; MLS2052; GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime
    货号: abs812010
    CAS号: 667463-62-9
    分子式: C16H10BrN3O2
    分子量: 356.17
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs812010-5mg 1-2周 ¥842.00
    - +
    abs812010-10mg 1-2周 ¥1222.00
    - +
    abs812010-50mg 1-2周 ¥5286.00
    - +
    大包装询价
    产品描述
    描述

    BIO是一种特异性的GSK-3抑制剂,无细胞试验中作用于GSK-3α/β的IC50为5 nM,比作用于CDK5选择性高16倍以上,也是一种泛JAK抑制剂。

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    6BIO; 6-BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052; MLS2052; GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime
    外观
    red brown to purple solid
    可溶性/溶解性
    DMSO :71 mg/mL (199.34 mM)

    Ethanol :21 mg/mL (58.96 mM)
    生物活性
    靶点
    GSK-3
    In vitro(体外研究)
    BIO is a specific inhibitor of glycogen synthase kinase-3 (GSK-3), with IC50 of 5 nM for GSK-3α/β, shows > 16-fold selectivity over CDK5. BIO interacts within the ATP binding pocket of these kinases, reduces β-catenin phosphorylation on a GSK-3-specific site in cellular models, closely mimicks Wnt signaling in Xenopus embryos. In human and mouse embryonic stem cells, BIO maintains the undifferentiated phenotype and sustains expression of the pluripotent state-specific transcription factors Oct-3/4, Rex-1 and Nanog. BIO-mediated Wnt activation is functionally reversible, as withdrawal of the compound leads to normal multidifferentiation programs in both human and mouse embryonic stem cells. BIO promotes proliferation in mammalian cardiomyocytes. 6BIO is also a pan-JAK inhibitor, with IC50 values of 0.03, 1.5, 8.0, 0.5 μM for TYK2, JAK1, JAK2 and JAK3, respectively. BIO selectively inhibits phosphorylation of STAT3 and induces apoptosis of human melanoma cells.
    In vivo(体内研究)
    BIO (50 mg/kg, p.o.) suppresses melanoma tumor growth in a mouse xenograft model.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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