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  • BI 224436
    货号: abs818939
    CAS号: 1155419-89-8
    分子式: C27H26N2O4
    分子量: 442.51
    产品说明书
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    货号-规格 货期 价格 数量
    abs818939-2mg 1-2周 ¥4116.00
    - +
    abs818939-5mg 1-2周 ¥6174.00
    - +
    大包装询价
    产品描述
    描述
    BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    HIV Integrase
    In vitro(体外研究)
    BI 224436 has cellular cytotoxicity of more than 90 μM. BI 224436 has a low, 2.1-fold decrease in antiviral potency in the presence of 50% human serum. BI 224436 retains full antiviral activity against recombinant viruses encoding INSTI resistance substitutions N155S, Q148H, and E92Q. BI 224436 displays an additive effect in combination with most approved antiretrovirals, including INSTIs. BI 224436 has drug-like in vitro absorption, distribution, metabolism, and excretion (ADME) properties, including Caco-2 cell permeability, solubility, and low cytochrome P450 inhibition.
    In vivo(体内研究)
    BI 224436 exhibits excellent pharmacokinetic profiles in rat (clearance as a percentage of hepatic flow , 0.7%; bioavailability , 54%), monkey (CL, 23%; F, 82%), and dog (CL, 8%; F, 81%).
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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