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  • β-Amanitin
  • 货号: abs42029909
    CAS号: 21150-22-1
    分子式: C39H53N9O15S
    分子量: 920.0
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    货号-规格 货期 价格 数量
    abs42029909-1mg 4周 ¥2535.00
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    产品描述
    描述

    β-Amanitin is an extremely toxic constituent of the mushroom, Amanita phalloides, that inhibits Rpb (eukaryotic RNA polymerase II) and eukaryotic RNA polymerase III. This toxin is synthesized as a proprotein, on ribosomes, 34 to 35 amino acids in length and then cleaved at specific proline residues by an enzyme belonging to the prolyl oligopeptidase (POP) subfamily. β-Amanitin shows remarkable binding affinity for eukaryotic RNA polymerase II, slightly binds to RNA polymerase III, and shows no activity on RNA polymerase I; it has been used to determine which types of RNA polymerase are present in a given sample. The toxin works by binding to the bridging helix of RNA polymerase II inhibiting the translocation of RNA and DNA needed to empty the site for the next round of synthesis; thereby slowing the rate of transcription by over 1000 fold.

    应用
    A specific and potent inhibitor of eukaryotic RNA polymerase II and a mild inhibitor of RNA polymerase III
    纯度
    ≥95%
    储存/保存方法
    Store at -20° C
    基本信息
    外观
    White to off-white powder.
    可溶性/溶解性
    Soluble in water (1 mg/ml), ethanol, methanol, DMSO, and DMF.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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