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  • Recombinant Human β-2-Microglobulin/B2M (C-6His)
  • Beta-2-Microglobulin, B2M
  • 货号: abs04343
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs04343-10ug 1-2周 ¥882.00
    - +
    abs04343-50ug 1-2周 ¥2646.00
    - +
    abs04343-500ug 1-2周 ¥12936.00
    - +
    abs04343-1mg 1-2周 ¥17600.00
    - +
    大包装询价
    概述
    描述

    Recombinant Human beta-2-Microglobulin is produced by our Mammalian expression system and the target gene encoding Ile21-Met119 is expressed with a 6His tag at the C-terminus.

    别名
    Beta-2-Microglobulin, B2M
    来源
    Human Cells
    形态
    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
    性能
    氨基酸序列
    IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLL YYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMVDHHHHHH
    纯度
    Greater than 95% as determined by reducing SDS-PAGE.
    内毒素水平
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
    溶解方法
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    储存/保存方法
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    靶标
    背景说明
    β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
    Accession
    P61769
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