伯尔尼霉素A

Berninamycin A is a member of the thiopeptide antibiotic family, which is described to contain sulfur and highly modified cyclic peptides. The compound has been reported to induce the tipA gene, which produces the proteins TipAL and TipsAS, that belong to the MerR family of transcription regulators. Studies indicate that Berninamycin A is a major component of Berninamycin. Berninamycin is described to affect the function of the ribosomal A site, act as a vigorous inhibitor of protein synthesis in gram-positive bacteria, and has the same mode of action as Thiostrepton . Studies report that Berninamycin A is isolated from Streptomyces and is structurally related to sulfomycin I. Other Berninamycins include Berninamycin B, C, and D .

Streptomycessp.

An antibiotic that contains sulfur and highly modified cyclic peptides

>99%

Store at -20° C

Solid

1.53 g/cm³ (Predicted)

n²⁰_D 1.68 (Predicted)

Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)

MFCD14635430

16156770