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  • Benzenesulfonamide

    • 苯磺酰胺
    货号: abs814484
    CAS号: 98-10-2
    分子式: C6H7NO2S
    分子量: 157.19
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    货号-规格 货期 价格 数量
    abs814484-100mg 1-2周 ¥776.00
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    abs814484-500mg 1-2周 ¥2329.00
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    产品描述
    描述

    Benzenesulfonamide, the amide of benzenesulfonic acid, has been used to produce various derivatives, especially those used as intermediates in the synthesis of photochemicals, dyes, disinfectants, as well as pharmaceuticals. 

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    苯磺酰胺
    外观
    白色结晶性粉末
    可溶性/溶解性
    DMSO : 29 mg/mL (184.5 mM)

    Ethanol : 29 mg/mL (184.5 mM)
    生物活性
    靶点
    Carbonic anhydrase
    In vitro(体外研究)
    In a previous study, a series of N-aryl-β-alanine- and diazo-derivatives of benzenesulfonamide were designed, synthesized, and their binding affinities to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was investigated by the use of isothermal titration calorimetry and fluorescent thermal shift assay. The results indicated that 4-substituted diazobenzenesulfonamides were found to be most potent CA binders among the synthesized derivatives. In addition, the majority of the N-aryl-β-alanine derivatives had better affinity for CA II while diazobenzenesulfonamides showed nanomolar affinities towards CA I isozyme. Moreover, the X-ray crystallographic data showed the binding modes of both derivative groups .
    In vivo(体内研究)
    In the rat CPE model, the most potnet benzenesulfonamide indole derivative at 10 mg/kg in the MC/TW formulation displayed oral efficacy. Moreover, this compound, when administered in another preferred, minimal formulation in the same in vivo model, demonstrated superior oral efficacy to the lead phenylmethane sulfonamide WAY-196025 orally administered in a lipid-based formulation. In addition, this benzenesulfonamide indole derivative was also orally efficacious at 1 mg/kg by attenuating both LAR and the associated AHR to aerosolized carbachol in naturally sensitized sheep, which had been challenged through the airways with A. suum antigen.
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    • 实验方法 实验条件
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