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  • BEC HCl
  • 货号: abs816171
    CAS号: 222638-67-7
    分子式: C5H12BNO4S.ClH
    分子量: 229.49
    产品说明书
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    货号-规格 货期 价格 数量
    abs816171-5mg 1-2周 ¥920.00
    - +
    abs816171-25mg 1-2周 ¥3039.00
    - +
    大包装询价
    产品描述
    描述

    BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

    纯度
    99%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    可溶性/溶解性
    DMSO :45 mg/mL (196.08 mM)

    Water :45 mg/mL (196.08 mM)

    Ethanol :45 mg/mL (196.08 mM)
    生物活性
    靶点
    Arginase II,rat Arginase I
    In vitro(体外研究)
    BEC causes significant enhancement of NO-dependent smooth muscle relaxation. In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK.
    In vivo(体内研究)
    In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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