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  • BAY11-7085
  • BAY 11-7085; BAY-11-7085; BAY 11-7083
  • 货号: abs812008
    CAS号: 196309-76-9
    分子式: C13H15NO2S
    分子量: 249.33
    产品说明书
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    货号-规格 货期 价格 数量
    abs812008-10mg 现货 ¥714.00
    - +
    abs812008-25mg 现货 ¥1575.00
    - +
    大包装询价
    产品描述
    描述

    BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    BAY 11-7085; BAY-11-7085; BAY 11-7083
    外观
    white solid
    可溶性/溶解性
    DMSO : 24.9 mg/mL (100 mM)

    Ethanol : 24.9 mg/mL (100 mM)
    生物活性
    靶点
    IκBα phosphorylation
    In vitro(体外研究)
    BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel. Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells.
    In vivo(体内研究)
    BAY 11-7085 inhibits the meningitis-associated increase in NF-κB activity, and results in an improvement of the clinical status of infected rats and a marked attenuation of meningitis-associated CNS complications and meningeal inflammation. BAY 11-7085 increases the efficacy of paclitaxel-induced inhibition of intraabdominal dissemination and production of ascites in athymic nude mice bearing Caov-3 cells.
    参考文献
    参考文献
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