(S)-(-)-Bay K 8644
- Bay-K-8644 ((S)-(-)-);(-)-BAY-R-5417;(-)-BAY-K-8644
货号: abs814567
货号-规格 | 货期 | 价格 | 数量 |
abs814567-5mg | 4周 | ¥1637.00 | - + |
abs814567-10mg | 4周 | ¥3652.00 | - + |

产品描述 | ||
描述 | Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM). | |
纯度 | ≥98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
形态 | Solid | |
基本信息 | ||
别名 | Bay-K-8644 ((S)-(-)-);(-)-BAY-R-5417;(-)-BAY-K-8644 | |
外观 | yellow powder | |
密度 | 1.37 g/cm3 (Predicted) | |
熔点 | 170.90° C (Predicted) | |
沸点 | 429.17° C at 760 mmHg (Predicted) | |
折射率 | n20D 1.54 (Predicted) | |
光学活性 | α20/D -50°, c = 0.44 in 1,4-dioxane | |
IC50 | Transient receptor potential cation channel subfamily A member 1: EC5050 = 41.5 µM (mouse) | |
Ki 数据 | Adenosine A1 receptor: Ki= 6.66 µM (rat); Adenosine A3-R: Ki= 23.5 µM (human); Adenosine A2a receptor: Ki= 86.3 µM (rat) | |
可溶性/溶解性 | DMSO : ≥ 310 mg/mL (870.05 mM) | |
MDL | MFCD00153769 | |
PubChem CID | 6603728 | |
生物活性 | ||
靶点 | IBa | |
In vitro(体外研究) | (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and Bay-K-8644 (S)-(-)- as an agonist. Bay-K-8644 (S)-(-)- can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum. The Ca2+ channel activity is enhanced by 3–30 μM Bay-K-8644 (S)-(-)-, an agonist of L-type Ca2+ channels. The interactions of two Ca2+ channel activators Bay-K-8644 (S)-(-)- and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by Bay-K-8644 (S)-(-)- (EC50=14 nM). Bay-K-8644 (S)-(-)- (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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