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  • (S)-(-)-Bay K 8644

    • Bay-K-8644 ((S)-(-)-);(-)-BAY-R-5417;(-)-BAY-K-8644
    货号: abs814567
    CAS号: 98625-26-4
    分子式: C16H15F3N2O4
    分子量: 356.3
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    货号-规格 货期 价格 数量
    abs814567-5mg 4周 ¥1637.00
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    abs814567-10mg 4周 ¥3652.00
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    大包装询价
    产品描述
    描述

    Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).

    纯度
    ≥98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    形态
    Solid
    基本信息
    别名
    Bay-K-8644 ((S)-(-)-);(-)-BAY-R-5417;(-)-BAY-K-8644
    外观
    yellow powder
    密度
    1.37 g/cm3 (Predicted)
    熔点
    170.90° C (Predicted)
    沸点
    429.17° C at 760 mmHg (Predicted)
    折射率
    n20D 1.54 (Predicted)
    光学活性
    α20/D -50°, c = 0.44 in 1,4-dioxane
    IC50
    Transient receptor potential cation channel subfamily A member 1: EC5050 = 41.5 µM (mouse)
    Ki 数据
    Adenosine A1 receptor: Ki= 6.66 µM (rat); Adenosine A3-R: Ki= 23.5 µM (human); Adenosine A2a receptor: Ki= 86.3 µM (rat)
    可溶性/溶解性
    DMSO : ≥ 310 mg/mL (870.05 mM)
    MDL
    MFCD00153769
    PubChem CID
    6603728
    生物活性
    靶点
    IBa
    In vitro(体外研究)
    (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and Bay-K-8644 (S)-(-)- as an agonist. Bay-K-8644 (S)-(-)- can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum. The Ca2+ channel activity is enhanced by 3–30 μM Bay-K-8644 (S)-(-)-, an agonist of L-type Ca2+ channels. The interactions of two Ca2+ channel activators Bay-K-8644 (S)-(-)- and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by Bay-K-8644 (S)-(-)- (EC50=14 nM). Bay-K-8644 (S)-(-)- (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.
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    • 实验方法 实验条件
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