(R)-(+)-Bay-K-8644

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba²⁺ currents (IBa) (IC₅₀=975 nM).

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Bay-K-8644 ((R)-(+)-)；R-4407；NI-105；(+)-BAY-K-8644

yellow powder

α20_D +52.9º, c = 0.42 in 1,4-dioxane

Transient receptor potential cation channel subfamily A member 1: EC₅₀50 = 20.8 µM (mouse)

pK_a: 7.67 (Predicted), pK_b: 1.5 (Predicted)

Adenosine A1-R: K_i= 785 nM (mouse); Adenosine A3-R: K_i= 2.77 µM (human); Adenosine A3-R: K_i= 6.2 µM (rat); Adenosine A2A-R: K_i= 35.1 µM (rat)

DMSO : ≥ 300 mg/mL (841.99 mM)

6604881

IBa

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, Bay-K-8644 (R)-(+)- as an antagonist and S(-)-Bay K 8644 as an agonist. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). When Bay-K-8644 (R)-(+)- (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of Bay-K-8644 (R)-(+)- (0.5 μM), additional application of forskolin and sodium nitroprusside (SNP) further inhibits IBa. Bay-K-8644 (R)-(+)- is a calcium channel inhibitor.