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  • (R)-(+)-Bay-K-8644

    • Bay-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644
    货号: abs814566
    CAS号: 98791-67-4
    分子式: C16H15F3N2O4
    分子量: 356.3
    产品说明书
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    货号-规格 货期 价格 数量
    abs814566-10mg 4周 ¥1800.00
    - +
    abs814566-50mg 4周 ¥7200.00
    - +
    大包装询价
    产品描述
    描述
    (R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Bay-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644
    外观
    yellow powder
    光学活性
    α20D +52.9º, c = 0.42 in 1,4-dioxane
    IC50
    Transient receptor potential cation channel subfamily A member 1: EC5050 = 20.8 µM (mouse)
    PK值
    pKa: 7.67 (Predicted), pKb: 1.5 (Predicted)
    Ki 数据
    Adenosine A1-R: Ki= 785 nM (mouse); Adenosine A3-R: Ki= 2.77 µM (human); Adenosine A3-R: Ki= 6.2 µM (rat); Adenosine A2A-R: Ki= 35.1 µM (rat)
    可溶性/溶解性
    DMSO : ≥ 300 mg/mL (841.99 mM)
    PubChem CID
    6604881
    生物活性
    靶点
    IBa
    In vitro(体外研究)
    (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, Bay-K-8644 (R)-(+)- as an antagonist and S(-)-Bay K 8644 as an agonist. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). When Bay-K-8644 (R)-(+)- (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of Bay-K-8644 (R)-(+)- (0.5 μM), additional application of forskolin and sodium nitroprusside (SNP) further inhibits IBa. Bay-K-8644 (R)-(+)- is a calcium channel inhibitor.
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    • 实验方法 实验条件
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