(R)-(+)-Bay-K-8644
- Bay-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644
货号: abs814566
货号-规格 | 货期 | 价格 | 数量 |
abs814566-10mg | 4周 | ¥1800.00 | - + |
abs814566-50mg | 4周 | ¥7200.00 | - + |

产品描述 | ||
描述 | (R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM). | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | Bay-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644 | |
外观 | yellow powder | |
光学活性 | α20D +52.9º, c = 0.42 in 1,4-dioxane | |
IC50 | Transient receptor potential cation channel subfamily A member 1: EC5050 = 20.8 µM (mouse) | |
PK值 | pKa: 7.67 (Predicted), pKb: 1.5 (Predicted) | |
Ki 数据 | Adenosine A1-R: Ki= 785 nM (mouse); Adenosine A3-R: Ki= 2.77 µM (human); Adenosine A3-R: Ki= 6.2 µM (rat); Adenosine A2A-R: Ki= 35.1 µM (rat) | |
可溶性/溶解性 | DMSO : ≥ 300 mg/mL (841.99 mM) | |
PubChem CID | 6604881 | |
生物活性 | ||
靶点 | IBa | |
In vitro(体外研究) | (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, Bay-K-8644 (R)-(+)- as an antagonist and S(-)-Bay K 8644 as an agonist. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). When Bay-K-8644 (R)-(+)- (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of Bay-K-8644 (R)-(+)- (0.5 μM), additional application of forskolin and sodium nitroprusside (SNP) further inhibits IBa. Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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