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  • Bay 36-7620
  • 货号: abs818024
    CAS号: 232605-26-4
    分子式: C19H18O2
    分子量: 278.35
    产品说明书
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    货号-规格 货期 价格 数量
    abs818024-10mg 4周 ¥5565.00
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    大包装询价
    产品描述
    描述

    代谢型谷氨酸(mGlu)受体是G-蛋白偶联受体(GPCR),其作用主要是作为突触传递的调节剂,在许多生理和病理过程中发挥作用.BAY36-7620是强效的非竞争性mGlu1受体拮抗剂.. 

    纯度
    98%
    储存/保存方法
    Store at -20°C
    基本信息
    外观
    White solid
    可溶性/溶解性
    Soluble in DMSO > 10 mM
    生物活性
    靶点
    GPCRs
    In vitro(体外研究)
    BAY36-7620 is a potent and selective antagonist at mGlu1receptors and inhibits >60% of mGlu1a receptor constitutive activity (IC50 = 0.38 μM). BAY36-7620 is thus the first described mGlu1 receptor inverse agonist. Moreover, BAY36-7620 did not displace the [3H]quisqualate binding from the Glu-binding pocket, indicating that BAY36-7620 is a noncompetitive mGlu1 antagonist.
    In vivo(体内研究)
    BAY 36-7620 protected against pentylenetetrazole-induced convulsions in the mouse. As assessed in rats, BAY 36-7620 was devoid of the typical side effects of the ionotropic glutamate (iGlu) receptor antagonists phencyclidine and MK-801. Therefore, BAY 36-7620 did not disrupt sensorimotor gating, induce phencyclidine-like discriminative effects or stereotypical behavior, or facilitate intracranial self-stimulated behavior.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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