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  • Bay 65-1942 HCl
    货号: abs811077
    CAS号: 600734-06-3
    分子式: C22H26ClN3O4
    分子量: 431.91
    产品说明书
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    货号-规格 货期 价格 数量
    abs811077-5mg 4周 ¥4624.00
    - +
    abs811077-10mg 4周 ¥8346.00
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    大包装询价
    产品描述
    描述

    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    IKK
    In vitro(体外研究)
    Delivery of Bay 65-1942 prior to ischemia significantly decreases left ventricular infarct size compared with animals receiving vehicle. Compared with sham animals, animals receiving vehicle have a significant increase in the infarct-to-area at risk (AAR) ratio (70.7±3.4 vs. 5.8±3.4%, P.
    In vivo(体内研究)
    Inhibitors of MEK (AZD6244) and IKK (BAY 65-1942) are used at their IC50 concentrations, as determined by a 48 hour MTS assay, which achieve sufficient inhibition of kinase activity. MYL-R cells are treated for 24 hours with AZD6244 (5 µM), BAY 65-1942 (10 µM), or a combination of these inhibitors at the same concentrations. AZD6244 and BAY 65-1942 demonstrate synergistic inhibition of cell viability at the dose combination (5 µM AZD6244+10 µM BAY 65-1942), which correlates with IC75 (CI = 0.48±0.01). Synergism is also indicated at the IC50 (CI = 0.56±0.09) and IC90 (CI = 0.46±0.02) dose combinations reported by the software (CI values are the mean of three independent experiments, ± standard deviation). AZD6244 and BAY 65-1942 treatment induces 2- and 1.3-fold caspase 3/7 activation, respectively, compared to the DMSO-treated cells. Treatment with a combination of AZD6244 plus BAY 65-1942 leads to a 3.2-fold increase in caspase 3/7 activity.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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