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  • Bardoxolone Methyl
    • 甲基巴多索隆;RTA 402; TP-155;NSC 713200; NSC 713200; CDDO Methyl ester
    货号: abs813506
    CAS号: 218600-53-4
    分子式: C32H43NO4
    分子量: 505.69
    产品说明书
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    货号-规格 货期 价格 数量
    abs813506-10mg 现货 ¥509.00
    - +
    abs813506-50mg 现货 ¥1597.00
    - +
    abs813506-200mg 现货 ¥4322.00
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    大包装询价
    产品描述
    描述
    Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    甲基巴多索隆;RTA 402; TP-155;NSC 713200; NSC 713200; CDDO Methyl ester
    外观
    固体粉末
    可溶性/溶解性
    DMSO :20 mg/mL (39.5 mM)
    生物活性
    靶点
    IKK ;Nrf2;NF-κB
    In vitro(体外研究)
    Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon-Ƴ in mouse macrophages with IC50 of 0.1 nM. Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis. Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke.
    In vivo(体内研究)
    Bardoxolone Methyl (60 mg/kg) reduces the number, size, and severity of lung tumors in vivo. Bardoxolone Methyl significantly reduces the in vivo inflammatory cytokine response following LPS challenge, induces HO-1 protein expression in the spleen, and protects mice against lethal-dose LPS.
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