- 甲基巴多索隆;RTA 402; TP-155;NSC 713200; NSC 713200; CDDO Methyl ester
货号: abs813506
货号-规格 | 货期 | 价格 | 数量 |
abs813506-10mg | 现货 | ¥509.00 | - + |
abs813506-50mg | 现货 | ¥1597.00 | - + |
abs813506-200mg | 现货 | ¥4322.00 | - + |

产品描述 | ||
描述 | Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. | |
纯度 | >98% | |
储存/保存方法 | store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
基本信息 | ||
别名 | 甲基巴多索隆;RTA 402; TP-155;NSC 713200; NSC 713200; CDDO Methyl ester | |
外观 | 固体粉末 | |
可溶性/溶解性 | DMSO :20 mg/mL (39.5 mM) | |
生物活性 | ||
靶点 | IKK ;Nrf2;NF-κB | |
In vitro(体外研究) | Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon-Ƴ in mouse macrophages with IC50 of 0.1 nM. Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis. Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke. | |
In vivo(体内研究) | Bardoxolone Methyl (60 mg/kg) reduces the number, size, and severity of lung tumors in vivo. Bardoxolone Methyl significantly reduces the in vivo inflammatory cytokine response following LPS challenge, induces HO-1 protein expression in the spleen, and protects mice against lethal-dose LPS. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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