Azelastine hydrochloride
- 盐酸氮卓斯汀
货号: abs816347
货号-规格 | 货期 | 价格 | 数量 |
abs816347-100mg | 1-2周 | ¥447.00 | - + |
abs816347-200mg | 1-2周 | ¥679.00 | - + |

产品描述 | ||
描述 | Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist. Azelastine hydrochloride (Astelin) has a triple mode of action: Anti-histamine effect, mast-cell stabilizing effect and anti-inflammatory effect. Azelastine hydrochloride (Astelin) has a rapid onset of action: 15 minutes with the nasal spray and 3 minutes with the eye drops. The effect lasts for 12 hours. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 盐酸氮卓斯汀 | |
外观 | 白色至类白色结晶性粉末 | |
可溶性/溶解性 | Ethanol :84 mg/mL (200.78 mM) DMSO :35 mg/mL (83.66 mM) Water :35 mg/mL (83.66 mM) | |
生物活性 | ||
靶点 | Histamine receptor | |
In vitro(体外研究) | Azelastine inhibits Ag- and ionomycin-induced TNF-alpha release with IC50 values of 25.7 mM and 1.66 mM, respectively, in a rat mast RBL-2H3 cell line. Azelastine also inhibits TNF-alpha mRNA expression, TNF-alpha protein synthesis and release, and, possibly related to these effects, Ca2+ influx, in Ag-stimulated cells. Azelastine inhibits TNF-alpha release to a greater extent than mRNA expression/protein synthesis and Ca2+ influx in ionomycin-stimulated cells, suggesting that Azelastine inhibits the release process more potently than transcription or production of TNF-alpha by interfering with a signal other than Ca2+. Azelastine added 1 hour after ionomycin stimulation also immediately blocks subsequent release of TNF-alpha, which has been produced in the cells, without affecting Ca2+ influx. Azelastine inhibits ionomycin-induced, but not Ag-induced, protein kinase C translocation to the membranes. Azelastine hydrochloride (Azeptin) dose-dependently suppresses both DNA and protein synthesis in human gingival fibroblasts (HF) and also suppresses blastogenesis of human peripheral blood lymphocytes (PBL). Azelastine hydrochloride (Azeptin) suppresses both inducible nitric oxide synthase-mRNA level and NO generation in mouse peritoneal macrophages. Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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