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  • AZD9056 hydrochloride

    货号: abs819008
    CAS号: 345303-91-5
    分子式: C24H36Cl2N2O2
    分子量: 455.46
    产品说明书
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    货号-规格 货期 价格 数量
    abs819008-5mg 1-2周 ¥1150.00
    - +
    abs819008-10mg 1-2周 ¥1920.00
    - +
    大包装询价
    产品描述
    描述
    AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO: ≥ 34 mg/mL
    生物活性
    靶点
    P2X Receptor
    In vitro(体外研究)
    The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line, indicating a high selectivity of the antagonist for the P2X7 receptor. The P2X7-receptor antagonist AZD9056 has a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells. AZD9056 is an inhibitor of BCRP and weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
    In vivo(体内研究)
    Treatment with AZD9056 exerts pain-relieving and anti-inflammatory effects. The upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP) and prostaglandin E2 (PGE2) which is induced by MIA in cartilage tissues is reversed by AZD9056.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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