AZD3965
- AZD-3965
货号： abs816101
| 货号-规格 | 货期 | 价格 | 数量 |
| abs816101-5mg | 现货 | ￥1613.00 | - + |
| abs816101-20mg | 现货 | ￥4961.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1. | |
| 纯度 | ≥98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | AZD-3965 | |
| 可溶性/溶解性 | DMSO : 100 mg/mL (193.98 mM; Need ultrasonic) | |
| 生物活性 | ||
| 靶点 | MCT1 | |
| In vitro(体外研究) | In lymphoma cell lines that preferentially express MCT1, AZD3965 potently inhibits lactate transport and cell growth. AZD3965 inhibits MCT1 activity in cells, and shows higher sensitivity in hypoxia. In H526, HGC27 cells and DMS114 cells, AZD3965 increases intracellular lactate and significantly reduces lactate uptake. | |
| In vivo(体内研究) | In nonobese diabetic scid-γ mice bearing COR-L103 xenografts, AZD3965 (100 mg/kg, p.o.) reduces tumor growth and increased intratumor lactate. In mice bearing H526 tumors, AZD3965 (100 mg/kg, p.o.) causes increased lactate concentration, a reduction in growth and increased radiation sensitivity. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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